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Guest allanopie

Cerebral Small-vessel Disease And Decline In Information Processing Speed, Executive Function And Memory

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Guest allanopie

Brain Advance Access originally published online on June 9, 2005

Brain 2005 128(9):2034-2041; doi:10.1093/brain/awh553

Articles by Breteler, M. M. B.

© The Author (2005). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

Cerebral small-vessel disease and decline in information processing speed, executive function and memory

Niels D. Prins1,2, Ewoud J. van Dijk1,2, Tom den Heijer1,2, Sarah E. Vermeer1,2, Jellemer Jolles3, Peter J. Koudstaal1, Albert Hofman2 and Monique M. B. Breteler2

1 Department of Neurology and 2 Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam and 3 Department of Neuropsychology, Psychiatry and Psychobiology, University of Maastricht, Maastricht, The Netherlands

Correspondence to: M. M. B. Breteler MD PhD, Department of Epidemiology, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands E-mail: m.breteler@erasmusmc.nl

Cerebral small-vessel disease is common in older people and may contribute to the development of dementia. The objective of the present study was to evaluate the relationship between measures of cerebral small-vessel disease on MRI and the rate of decline in specific cognitive domains in participants from the prospective, population-based Rotterdam Scan Study. Participants were 60–90 years of age and free from dementia at baseline in 1995–1996. White matter lesions (WML), cerebral infarcts and generalized brain atrophy were assessed on the baseline MRI. We performed neuropsychological testing at baseline and repeatedly in 1999–2000 and in 2001–2003. We used random-effects models for repeated measures to examine the association between quantitative MRI measures and rate of decline in measures of global cognitive function, information processing speed, executive function and memory. There were a total of 2266 assessments for the 832 participants in the study, with an average time from the initial to last assessment of 5.2 years. Increasing severity of periventricular WML and generalized brain atrophy and the presence of brain infarcts on MRI were associated with a steeper decline in cognitive function. These structural brain changes were specifically associated with decline in information processing speed and executive function. The associations between MRI measures of cerebral small-vessel disease and cognitive decline did not change after additional adjustment for vascular risk factors or depressed mood. After exclusion of participants with an incident stroke, some of the associations of periventricular WML, brain infarcts and generalized brain atrophy with measures of information processing speed and executive function were no longer significant. This may indicate that stroke plays an intermediate role in the relationship between cerebral small-vessel disease and cognitive decline. Our results suggest that in older people cerebral small-vessel disease may contribute to cognitive decline by affecting information processing speed and executive function.

Key Words: ischaemic leucoaraiosis; lacunar infarction; MRI; executive function; cognitive function

Abbreviations: APOE = apolipoprotein E gene; MMSE = Mini-Mental State Examination; WML = white matter lesions

Received May 20, 2004. Revised October 9, 2004. Second revision April 23, 2005. Accepted May 3, 2005.

Source: http://brain.oxfordjournals.org/cgi/conten...ract/128/9/2034

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