Jump to content
  • Advertisemnt

  • 14 Questions about VA Disability Compensation Benefits Claims


    When a Veteran starts considering whether or not to file a VA Disability Claim, there are a lot of questions that he or she tends to ask. Over the last 10 years, the following are the 14 most common basic questions I am asked about ...
    Continue Reading
  • Ads

  • Most Common VA Disabilities Claimed for Compensation:   


  • Advertisemnt

  • VA Watchdog

  • Advertisemnt

  • Ads

  • Can a 100 percent Disabled Veteran Work and Earn an Income?

    employment 2.jpeg

    You’ve just been rated 100% disabled by the Veterans Affairs. After the excitement of finally having the rating you deserve wears off, you start asking questions. One of the first questions that you might ask is this: It’s a legitimate question – rare is the Veteran that finds themselves sitting on the couch eating bon-bons … Continue reading

  • Searches Community Forums, Blog and more

  • Ad Free Subscription.jpgOne Time Financial Gift.jpg

    Subscriptions and Gifts are NOT Tax Deductible. HadIt.com is NOT a Non Profit.

Guest allan

Effects Of Gabapentin And Carbamazepine On The Eeg And Cognition In Healthy Volunteers.

Recommended Posts

Guest allan

1: Epilepsia., 2002 May;43(5):482-90.

Effects of gabapentin and carbamazepine on the EEG and cognition in healthy volunteers.

Salinsky MC, Binder LM, Oken BS, Storzbach D, Aron CR, Dodrill CB.

Oregon Health Sciences University Epilepsy Center, Portland, Oregon 97201, USA. Salinsky@OHSU.edu

PURPOSE: Antiepileptic drug (AED) therapy can be associated with neurotoxic side effects including cognitive dysfunction. Objective methods for detection of neurotoxicity in individual patients would be useful. We studied the effects of gabapentin (GBP) and carbamazepine (CBZ) on neurophysiologic and cognitive/behavioral measures in healthy volunteers. METHODS: In a 12-week, randomized, double-blind, parallel-group study of CBZ and GBP in healthy volunteers, 23 subjects completed the protocol. All achieved the target dose of 1,200 mg CBZ or 3,600 mg GBP. A structured EEG for quantitative analysis and a cognitive test battery were administered before AED therapy and again after 12 weeks of therapy. Test-retest differences were compared with those of 72 untreated control subjects. RESULTS: Both CBZ and GBP significantly decreased the peak frequency of the posterior (alpha) rhythm, with CBZ exerting a greater effect. Ten CBZ and six GBP subjects exceeded the 95% confidence interval (CI) for an individual. Cognitive tests revealed AED vs. control group effects for two of seven measures (Digit Symbol, Stroop) and all subjective measures. However, few subjects exceeded the 95% CI for any objective test. Differences between CBZ and GBP were not significant. Greater EEG slowing was associated with greater subjective neurotoxicity and poorer test-retest performance on a cognitive test summary measure. CONCLUSIONS: Prolonged CBZ and GBP therapy induced EEG slowing that correlated with cognitive complaints and often exceeded the confidence interval for individual subjects. Quantitative EEG measures may be useful in the objective determination of AED-related neurotoxicity.

Publication Types:

Clinical Trial,

Comparative Study ,

Randomized Controlled Trial,

Research Support, Non-U.S. Gov't ,

MeSH Terms:

Acetic Acids/pharmacology*,

Acetic Acids/therapeutic use,



Alpha Rhythm/drug effects,


Anticonvulsants/adverse effects,


Anticonvulsants/therapeutic use,

Brain/drug effects*,


Carbamazepine/therapeutic use,

Cognition/drug effects*,

Cyclohexanecarboxylic Acids*,

Dose-Response Relationship, Drug,

Double-Blind Method,

Drug Administration Schedule,

Electroencephalography/drug effects*,

Epilepsy/drug therapy,



Middle Aged,

Neuropsychological Tests/statistics & numerical data,

Regression Analysis,

gamma-Aminobutyric Acid*,


Acetic Acids,



Cyclohexanecarboxylic Acids,


gamma-Aminobutyric Acid,


PMID: 12027908 [PubMed - indexed for MEDLINE]




Share this post

Link to post
Share on other sites


I take 300 x 3 or 900 mg a day of gabapentin. I do not know what I would do without it. 3600 a day is a pretty large dose although there are short periods of time I took doses like that.

Share this post

Link to post
Share on other sites
Guest allan

Hello Pete,

when I took Gabapentin last, I was on 2700mg daily. It helped the pain, but I couldn't tolerate the side effects.

I'm glad it helps you & it's good to know some of these things work.

Share this post

Link to post
Share on other sites

I take 3600 mg of Gabentin along with 1800 mg of Trileptal (another anti-seziure med) and Cymbalta 3 x's a day for central nerve damage due to stroke. The side effects are tremendous. I do no know how my family puts up with me. However, it does take my 24/7 pain from a 10 to about a 7 so I do get some benefit. Doc says the cocktail is the only thing capable of providing any relief as the narcotic pain killers only make me a drunk with an enormous pain problem.

Share this post

Link to post
Share on other sites

Would Dilantin or Lamictal fall into this category ?



Share this post

Link to post
Share on other sites
This topic is now closed to further replies.

  • Our picks

    • Type 1 Diabetes recent onset!
      I was diagnosed with Type 1 diabetes in September 2017 OUT OF NOWHERE.

      i am a Navy Reservist and deployed in later 2009 to mid 2010 and again later 2014 to mid 2015; had a 2 year recall between those deployments.  

      Only healthcare received since commissioning in 2008 was from the Navy and no issues EVER.

      insulin dependent and have dietary restrictions and in a non deployable status.

      VA denied initial claim due to Type 1 not showing on active duty and now appealing.

      Anyone with successful experience getting a rating with my circumstances?  I live in Upstate New York.
      • 9 replies
    • Agent Orange Kadena Afb Okinawa
      I am looking for anyone who was on Kadena AFB, Okinawa or .Chanute AFB, IL. My dad was there from Oct. 68-April 70. He has ichemic heart disease, diabetes which has resulted in the amputation of his right leg below the knee and peripheral neuropathy. We were denied in 2002 AMVETS filed a claim on his behalf for heart condition, diabetes and back problems. I refiled in December 2011 and have just received the claim statements and medical release forms. I am familiar with filling out this paper work because my husband is a combat veteran of Iraqi Freedom. I have been reading articles from the Japan times and I am a member of the Agent Orange Okinawa facebook page. Another thing that helps make my dad's case is that he was on Chanute AFB, IL and it is on the EPA Superfund list and has PCBs/Pesticides and Dioxins/Furans listed as ground and water contaminants. I welcome any advice, tips or articles that I may have missed in my own research.
        • Like
      • 15 replies
    • CBO Options for Reducing the Deficit: 2019 to 2028 Published Dec 2018
      CBO Options for Reducing the Deficit: 2019 to 2028 - This CBO Report has been making the news. This post includes parts relevant to veterans. Nothing has been decided as of yet and some seem very unlikely but you never know. Forewarned is Forearmed.


      • 8 replies
    • 2019 Veterans Benefits
      State Benefits, Space A and More ... https://www.hadit.com/2019-changes-to-veterans-benefits-state-and-federal/
      • 2 replies
    • Appeal granted and closed.
      My appeal was granted and closed on November 9.  I got an unofficial notification from the DAV on November 15 stating "appeal granted with an evaluation of 30%" which is great!  My question is this:  How long until I get the official notification from the va? Nothing on ebennies has updated since the appeal closed. Appeal is now in historical and just says complete and at originating va office. I understand no one knows va timelines to a tee but a general timeline would be great.  Thank you all! Hope you have a Merry Christmas!


      Edit:  This was my first time appealing and it was a VBA grant. 
        • Like
      • 6 replies
  • Ads

  • Popular Contributors

  • Ad

  • Latest News

Important Information

{terms] and Guidelines