Jump to content
VA Disability Community via Hadit.com

VA Disability Claims Articles

Ask Your VA Claims Question | Current Forum Posts Search | Rules | View All Forums
VA Disability Articles | Chats and Other Events | Donate | Blogs | New Users

  • homepage-banner-2024-2.png

  • donate-be-a-hero.png

Cognitive And Psychomotor Effects Of Paroxetine And Sertraline On Healthy Elderly Volunteers.

Rate this topic


Guest allan

Recommended Posts

1: Am J Geriatr Psychiatry, 2001 Fall;9(4):429-38.Related Articles, http:--highwire.stanford.edu-icons-externalservices-pubmed-notfree-ajgp-entrez.gif

Cognitive and psychomotor effects of paroxetine and sertraline on healthy elderly volunteers.

Furlan PM, Kallan MJ, Ten Have T, Pollock BG, Katz I, Lucki I.

Department of Psychiatry, University of Pennsylvania, 3600 Market St., Philadelphia, PA 19104, USA.

The authors evaluated the cognitive and psychomotor effects of serotonin reuptake inhibitors in healthy elderly volunteers. Paroxetine, sertraline, and placebo were compared for 3 weeks of testing in a double-blind study with behavioral testing at baseline and at the end of each week. MANOVA models demonstrated no between-group differences; however, mixed-model random regression analyses revealed that Day 14 plasma paroxetine levels correlated negatively with delayed verbal recall and paired-associate learning scores. In contrast, plasma sertraline levels correlated positively with Day 7 immediate verbal recall, Day 14 tapping, and Day 21 delayed verbal recall scores, and negatively with divided-attention task scores on Day 21. Plasma paroxetine levels were associated with mild behavioral impairment at Day 14, with no other significant adverse effects. Plasma sertraline levels were associated with mild and transient behavioral changes, as well as early termination in several subjects.


PMID: 11739070 [PubMed - indexed for MEDLINE]

Edited by allan
Link to comment
Share on other sites

  • Replies 0
  • Created
  • Last Reply

Popular Days

Guest
This topic is now closed to further replies.
×
×
  • Create New...

Important Information

Guidelines and Terms of Use