Brain Mri

[betrayed]

what does this mean?

[Guest allan]

Journal of Neurology Neurosurgery and Psychiatry 2005;76:362-367

© 2005 BMJ Publishing Group Ltd

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PAPER

White matter hyperintensities are related to physical disability and poor motor function

P S Sachdev1, W Wen1, H Christensen2 and A F Jorm2

1 School of Psychiatry, University of New South Wales, Sydney, NSW 2052, Australia

2 Centre for Mental Health Research, Australian National University, Canberra, 0200, Australia

Correspondence to:

Professor P Sachdev

NPI, Prince of Wales Hospital, Barker Street, Randwick NSW 2031, Australia; p.sachdev@unsw.edu.au

Objective: To determine the impact of white matter hyperintensities (WMHs) on physical health and cognitive function in 60–64 year old individuals residing in the community.

Methods: A subsample of 478 persons aged 60–64 from a larger community sample underwent brain magnetic resonance imaging (MRI) scans. WMHs on T2 weighted FLAIR (fluid attenuated inversion recovery) MRI scans were assessed using an automated procedure. Subjects were assessed for global cognitive function, episodic memory, working memory (digit span), information processing speed (Symbol Digit Modalities Test; SDMT), fine motor dexterity (Purdue Pegboard), and grip strength, and completed the Physical Component Summary of the Short Form Health Survey (SF-12). Regression analyses were used to examine the effect of WMHs on physical and cognitive function.

Results: Deep and periventricular WMHs were present in all subjects, with women having slightly more lesions than men. WMHs were significantly associated with poorer reported physical health on the SF-12 scale, after adjusting for depression, cognitive function, and brain atrophy. WMHs were also related to lower scores on the Purdue Pegboard test, grip strength, choice reaction time, and SDMT, but not on tests of episodic memory, working memory, general intellectual function, and global cognitive function. On regression analyses, the Purdue Pegboard test and grip strength were related to physical disability.

Conclusion: WMHs are common, albeit mild, in middle adult life. They are associated with physical disability, possibly through reduced speed, fine motor coordination, and muscular strength. They are also related to slowed information processing speed but not other cognitive functions.

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Abbreviations: CSF, cerebrospinal fluid; CVLT, California Verbal Learning Test; df, degrees of freedom; DWMH, deep white matter region; FLAIR, fluid attenuated inversion recovery; FOV, field of view; ICC, intraclass correlation; ICV, intracranial volume; MMSE, Mini Mental State Examination; MRI, magnetic resonance imaging; PVH, periventricular region; SDMT, Symbol Digits Modalities Test; SF-12, Physical Component Summary of the 12 Item Short Form Health Survey; TE, echo time; TR, repetition time; WMH, white matter hyperintensity

Keywords: white matter hyperintensities; physical health; motor speed; cognitive function; grip strength; magnetic resonance imaging

Source:

http://jnnp.bmj.com/cgi/content/abstract/76/3/362

[betrayed]

You are tooooo funny!!!!

I have a deviated septum too, but I wont have the surgery, because my nose is big enough already....hehe.

Enjoy!!!

I broke my nose on a windshield, (passenger) drunk. no seatbelt on, 2am 1977, 19 years old, In a souped up nova, looked at my bud who was driving and said lets see what this thing will do, we took off like a bat out of hell, long straightaway, was running redlights till we came to a red light with a car whose tail lights were out.

Lucky me all I got out of it was a broke nose and lots of glass embeddded in my skin( crap poped out here and ther for years. They took me to the navy ER when I said hey my nose is broke its way crooked, they said your nose isnt broke .

So anyway 3 days later I get sent to hospital and they say hey your nose is broke, I said no shit.............well guess what were gonna beak it again, right now..............numbed my face with shots of novicane then used liquid cocaine (written in my SMR) soaked in cotton and shoved up my nose....God what a fukcing high. The doc came over and put his hands on my face and used both thumbs to break it and move it over, The high was gone immediatley, I started sneezing blood, I was a miserablr SOB for three days. still little crooked, more of a hump then crooked.

Edited December 2, 2006 by FLHRCI

[betrayed]

Journal of Neurology Neurosurgery and Psychiatry 2005;76:362-367

http://jnnp.bmj.com/cgi/content/abstract/76/3/362

Thanks Allan!

[Guest allan]

Hello Chief,

The head of neurology, dismissed my white matter lesions in the subcortical region as, "possible" ischemia but healing well. In the mri's deferential, it stated Ischemia, Gliosis or demylenization as possible causes.

A resident at one of the "show & tell" sessions with his students, stated I didn't have anything wrong with me "neurologically" after his workup, but diagnosed me with "ataxia" & a "gate" problem.

One of the VA's leading neurologist that viewed my MRI last, completely missed the lesion in the corpus callosum. After I lost it & cussed him out, He found it. But stated it was faint & healing. Said I was in great shape. Than diagnosed TBI from either trauma or toxins.

An Independent Neurologist the VA sent me to, said he thought it was just depression, but notes a + babinski sign on left foot.

I had around a dozen high markers on my last blood draw, VAMC interpretation? "YOUR LABS LOOK FINE!"

You can expect half assed work at best & BS to cover the rest.

After a therough examination of all my records, including SMR's.

Dr Bash was able to provide a "firm" & complete diagnoses of MS out of the same medical records & one yr of inservice medical records & separation examination the VA blessed me with.

I learned the hard way. One slap in the face after another.

Your lesions " may" be played down as well. I can't say, since I'm no doctor or specialist. But would like to give all of you a heads up with neurology.

What ever you do, don't just take their word & run with it. Ask questions untill you get "clear" answers you understand.

If your getting neurologists telling you nothings wrong with you, but your labs have markers all over it, brain lesions on MRI's & neurological signs & symptoms in your medical history along with treatment, keep asking.

Much of VA's health care is the "mushroom treatment".

[tdak]

Holy crap, I would have died with all that pain. Thank goodness I have never broken anything, but I have had my rounds with stitches.

So I bet you stopped running red lights huh?

I broke my nose on a windshield, (passenger) drunk. no seatbelt on, 2am 1977, 19 years old, In a souped up nova, looked at my bud who was driving and said lets see what this thing will do, we took off like a bat out of hell, long straightaway, was running redlights till we came to a red light with a car whose tail lights were out.

Lucky me all I got out of it was a broke nose and lots of glass embeddded in my skin( crap poped out here and ther for years. They took me to the navy ER when I said hey my nose is broke its way crooked, they said your nose isnt broke .

So anyway 3 days later I get sent to hospital and they say hey your nose is broke, I said no shit.............well guess what were gonna beak it again, right now..............numbed my face with shots of novicane then used liquid cocaine (written in my SMR) soaked in cotton and shoved up my nose....God what a fukcing high. The doc came over and put his hands on my face and used both thumbs to break it and move it over, The high was gone immediatley, I started sneezing blood, I was a miserablr SOB for three days. still little crooked, more of a hump then crooked.